U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sym-1 Leucine-rich repeat-containing protein let-4 [ Caenorhabditis elegans ]

Gene ID: 181555, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
sym-1
Official Full Name
Leucine-rich repeat-containing protein let-4
Primary source
WormBase:WBGene00006366
Locus tag
CELE_C44H4.3
See related
AllianceGenome:WB:WBGene00006366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in extracellular space. Is expressed in vulB1 and vulB2. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sym-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (14581622..14584378)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chorein N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene ncRNA Neighboring gene TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Niwa R, et al. Cell Cycle, 2009 Dec 15. PMID 19923914, Free PMC Article
  2. The apical ECM preserves embryonic integrity and distributes mechanical stress during morphogenesis. Vuong-Brender TTK, et al. Development, 2017 Dec 1. PMID 28526752, Free PMC Article
  3. Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans. Mancuso VP, et al. Development, 2012 Mar. PMID 22278925, Free PMC Article
  4. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. Ito TK, et al. PLoS One, 2014. PMID 25057989, Free PMC Article
  5. The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Yochem J, et al. Genetics, 2004 Nov. PMID 15579686, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Leucine-rich repeat-containing protein let-4
NP_510426.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14581622..14584378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078025.7 → NP_510426.1  Leucine-rich repeat-containing protein let-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510426.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFP4
    Conserved Domains (5) summary
    cd00116
    Location:81 → 384
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:399 → 410
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:86 → 108
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13306
    Location:74 → 208
    LRR_5; Leucine rich repeats (6 copies)
    pfam13855
    Location:253 → 313
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools