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mgrn-1 RING-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 181537, updated on 9-Dec-2024

Summary

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Official Symbol
mgrn-1
Official Full Name
RING-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00007529
Locus tag
CELE_C11H1.3
See related
AllianceGenome:WB:WBGene00007529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of vulval development and protein localization to basolateral plasma membrane. Located in cytoplasmic vesicle. Is expressed in body wall musculature; nervous system; pharynx; and vulval precursor cell. Orthologous to human MGRN1 (mahogunin ring finger 1) and RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mgrn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (14307863..14311683, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Golgi pH regulator Neighboring gene ncRNA Neighboring gene AAA+ ATPase domain-containing protein;Peroxisomal ATPase PEX1 Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. Haag A, et al. PLoS Genet, 2014 May. PMID 24785082, Free PMC Article
  2. Detection of broadly expressed neuronal genes in C. elegans. Ruvinsky I, et al. Dev Biol, 2007 Feb 15. PMID 17046742
  3. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
  4. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923
  5. An RNAi screen identifies genes that regulate GABA synapses. Vashlishan AB, et al. Neuron, 2008 May 8. PMID 18466746

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RING-type E3 ubiquitin transferase
NP_510385.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14307863..14311683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077984.7 → NP_510385.1  RING-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17911
    Conserved Domains (3) summary
    COG5432
    Location:264 → 353
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16789
    Location:268 → 308
    mRING-HC-C3HC5_MGRN1_like---blasttree; Modified RING finger, HC subclass (C3HC5-type), found in mahogunin RING finger protein 1 (MGRN1), RING finger protein 157 (RNF157) and similar proteins
    pfam16228
    Location:382 → 522
    DUF4887; Domain of unknown function (DUF4887)
Nucleotide Protein
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