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akt-2 Serine/threonine-protein kinase akt-2 [ Caenorhabditis elegans ]

Gene ID: 181524, updated on 4-Jan-2025

Summary

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Official Symbol
akt-2
Official Full Name
Serine/threonine-protein kinase akt-2
Primary source
WormBase:WBGene00000103
Locus tag
CELE_F28H6.1
See related
AllianceGenome:WB:WBGene00000103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Is expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See akt-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (14147700..14152070)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene kynurenine--oxoglutarate transaminase Neighboring gene Homeodomain-only protein Neighboring gene Homeobox domain-containing protein Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways. Xu P, et al. Geroscience, 2023 Apr. PMID 36462128, Free PMC Article
  2. Lactobacillus fermentum WC2020 increased the longevity of Caenorhabditis elegans via JNK-mediated antioxidant pathway. Yang X, et al. J Food Sci, 2024 Jun. PMID 38638065
  3. [Effect of Ligusticum chuanxiong extract on lifespan of Caenorhabditis elegans and its underlying molecular mechanisms]. Wang X, et al. Zhongguo Zhong Yao Za Zhi, 2010 Apr. PMID 20617690
  4. Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Nawa M, et al. Cell Death Differ, 2012 Aug. PMID 22388351, Free PMC Article
  5. Reconstruction of the insulin-like signalling pathway of Haemonchus contortus. Mohandas N, et al. Parasit Vectors, 2016 Feb 3. PMID 26842675, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
Serine/threonine-protein kinase akt-2
NP_001024612.1
  • Confirmed by transcript evidence
NP_510357.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14147700..14152070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029441.4 → NP_001024612.1  Serine/threonine-protein kinase akt-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024612.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTG7
    Conserved Domains (4) summary
    smart00220
    Location:180 → 437
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:11 → 116
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    pfam00169
    Location:13 → 115
    PH; PH domain
    cl21453
    Location:184 → 468
    PKc_like; Protein Kinases, catalytic domain

  2. NM_077956.8 → NP_510357.3  Serine/threonine-protein kinase akt-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510357.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77145, Q9XTG7
    Conserved Domains (4) summary
    smart00220
    Location:180 → 437
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:11 → 116
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    pfam00169
    Location:13 → 115
    PH; PH domain
    cl21453
    Location:184 → 509
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTG7.1

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