dyc-1 Dystrophin-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dyc-1
Official Full Name: Dystrophin-like protein 1
Primary source: WormBase:WBGene00001116
Locus tag: CELE_C33G3.1
See related: AllianceGenome:WB:WBGene00001116
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: A structural constituent of muscle. Involved in several processes, including muscle cell cellular homeostasis; regulation of egg-laying behavior; and sarcomere organization. Located in axon and striated muscle dense body. Part of dystrophin-associated glycoprotein complex. Is expressed in SDQ; body wall musculature; head; intestinal cell; and muscle cell. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dyc-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (14049535..14063930)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein zyxin.
Title: DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33G3.1 (e-PCR)
- UniSTS:306045

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nitric-oxide synthase binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase regulator activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	IGI Inferred from Genetic Interaction more info	PubMed
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Dystrophin-like protein 1

NP_001024439.1

Confirmed by transcript evidence

NP_741925.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14049535..14063930

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029268.6 → NP_001024439.1 Dystrophin-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024439.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8STF6, Q93325, Q9XZQ6

Conserved Domains (3) summary

TIGR01628
Location:305 → 465

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd01270
Location:6 → 185

PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

pfam03154
Location:210 → 392

Atrophin-1; Atrophin-1 family
NM_171796.6 → NP_741925.2 Dystrophin-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741925.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8STF6

Conserved Domains (3) summary

pfam03153
Location:173 → 357

TFIIA; Transcription factor IIA, alpha/beta subunit

cl17171
Location:17 → 91

PH-like; Pleckstrin homology-like domain

cl23720
Location:345 → 425

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)