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pix-1 SH3 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181490, updated on 4-Jan-2025

Summary

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Official Symbol
pix-1
Official Full Name
SH3 domain-containing protein
Primary source
WormBase:WBGene00010776
Locus tag
CELE_K11E4.4
See related
AllianceGenome:WB:WBGene00010776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in several cellular components, including adherens junction; cell periphery; and hemidesmosome. Is expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to several human genes including ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pix-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (13727293..13734407)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene PON (paraoxonase) and MEC-6 Like Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-71 Neighboring gene Association with the SNF1 complex (ASC) domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Moody JC, et al. Nat Commun, 2020 Oct 6. PMID 33024114, Free PMC Article
  2. Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Dyer JO, et al. Small GTPases, 2010 Jul. PMID 21686119, Free PMC Article
  3. The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle. Moody JC, et al. Mol Biol Cell, 2024 Apr 1. PMID 38446619, Free PMC Article
  4. Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes. Martin E, et al. J Cell Biol, 2016 Nov 21. PMID 27821782, Free PMC Article
  5. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Zhang H, et al. Nature, 2011 Mar 3. PMID 21368832

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
    Title: The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
  2. pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans
    Title: pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.
  3. only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases
    Title: A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gonad morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inductive cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SH3 domain-containing protein
NP_001257227.1
  • Confirmed by transcript evidence
NP_001257228.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13727293..13734407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270298.4 → NP_001257227.1  SH3 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21430
    Conserved Domains (3) summary
    cd11877
    Location:11 → 62
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:93 → 261
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16523
    Location:554 → 637
    betaPIX_CC; betaPIX coiled coil

  2. NM_001270299.3 → NP_001257228.1  SH3 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W735
    Conserved Domains (2) summary
    cd11877
    Location:11 → 62
    SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
    cd00160
    Location:93 → 261
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Nucleotide Protein
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