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Npas2 neuronal PAS domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 18143, updated on 27-Nov-2024

Summary

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Official Symbol
Npas2provided by MGI
Official Full Name
neuronal PAS domain protein 2provided by MGI
Primary source
MGI:MGI:109232
See related
Ensembl:ENSMUSG00000026077 AllianceGenome:MGI:109232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MOP4; bHLHe9
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. The encoded protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Dec 2014]
Expression
Broad expression in small intestine adult (RPKM 16.1), colon adult (RPKM 13.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Npas2 in Genome Data Viewer
Location:
1 B; 1 17.98 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39233013..39402321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39193702..39363240)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35222 Neighboring gene STARR-seq mESC enhancer starr_00703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39148051-39148289 Neighboring gene STARR-seq mESC enhancer starr_00706 Neighboring gene STARR-seq mESC enhancer starr_00707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39249153-39249481 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39249871-39249980 Neighboring gene microRNA 6349 Neighboring gene predicted gene 20428 Neighboring gene microrchidia 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_00710 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 53549 Neighboring gene TBC1 domain family, member 8 Neighboring gene ribosomal protein L31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39535681-39535790 Neighboring gene STARR-seq mESC enhancer starr_00719 Neighboring gene predicted gene, 24826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction. Sasaki H, et al. Anat Rec (Hoboken), 2020 Jun. PMID 30851151, Free PMC Article
  2. Changes in pH and NADPH regulate the DNA binding activity of neuronal PAS domain protein 2, a mammalian circadian transcription factor. Yoshii K, et al. Biochemistry, 2015 Jan 20. PMID 25526362
  3. CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 2. Uchida T, et al. J Biol Chem, 2005 Jun 3. PMID 15797872
  4. Conditional postnatal deletion of the neonatal murine hepatic circadian gene, Npas2, alters the gut microbiome following restricted feeding. O'Neil DS, et al. Am J Obstet Gynecol, 2017 Aug. PMID 28373017, Free PMC Article
  5. Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. Hassan N, et al. PLoS One, 2017. PMID 28817668, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Npas2 and Per2 modifications in zinc-induced acute diurnal toxicity in mice.
    Title: Involvement of Npas2 and Per2 modifications in zinc-induced acute diurnal toxicity in mice.
  2. Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver.
    Title: Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver.
  3. A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice.
    Title: A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice.
  4. Circadian transcription factor NPAS2 and the NAD(+) -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward.
    Title: Circadian transcription factor NPAS2 and the NAD(+) -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward.
  5. Roles of NPAS2 in circadian rhythm and disease.
    Title: Roles of NPAS2 in circadian rhythm and disease.
  6. Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice.
    Title: Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice.
  7. Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction.
    Title: Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction.
  8. Here we have provided an initial key insight into the interplay between neonatal establishment of the peripheral circadian clock in the liver and the ability of the gut microbiome to respond to dietary and metabolic stress.
    Title: Conditional postnatal deletion of the neonatal murine hepatic circadian gene, Npas2, alters the gut microbiome following restricted feeding.
  9. In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.
    Title: NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
  10. Study identified a unique role for Npas2 in the regulation of cocaine reward and dopamine Drd3 receptor expression
    Title: Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129355

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within circadian sleep/wake cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to redox state IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to redox state ISO
Inferred from Sequence Orthology
more info
  
involved_in response to redox state ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CLOCK-BMAL transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuronal PAS domain-containing protein 2
Names
neuronal PAS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008719.2 → NP_032745.2  neuronal PAS domain-containing protein 2

    See identical proteins and their annotated locations for NP_032745.2

    Status: VALIDATED

    Source sequence(s)
    BB524729, BC109166, BG070037, U77969
    Consensus CDS
    CCDS48244.1
    UniProtKB/Swiss-Prot
    P97460
    UniProtKB/TrEMBL
    G3X9B7
    Related
    ENSMUSP00000054719.8, ENSMUST00000056815.9
    Conserved Domains (4) summary
    TIGR02813
    Location:440 → 740
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA
    pfam00989
    Location:84 → 195
    PAS; PAS fold
    pfam14598
    Location:249 → 352
    PAS_11; PAS domain
    cd19737
    Location:1 → 77
    bHLH-PAS_NPAS2_PASD4; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 2 (NPAS2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39233013..39402321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238452.4 → XP_011236754.1  neuronal PAS domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011236754.1

    UniProtKB/Swiss-Prot
    P97460
    UniProtKB/TrEMBL
    G3X9B7
    Conserved Domains (4) summary
    TIGR02813
    Location:440 → 740
    omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA
    pfam00989
    Location:84 → 195
    PAS; PAS fold
    pfam14598
    Location:249 → 352
    PAS_11; PAS domain
    cd19737
    Location:1 → 77
    bHLH-PAS_NPAS2_PASD4; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 2 (NPAS2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97460.1 GenPept UniProtKB/Swiss-Prot:P97460

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