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sdc-2 Sex determination and dosage compensation protein sdc-2 [ Caenorhabditis elegans ]

Gene ID: 181341, updated on 9-Dec-2024

Summary

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Official Symbol
sdc-2
Official Full Name
Sex determination and dosage compensation protein sdc-2
Primary source
WormBase:WBGene00004746
Locus tag
CELE_C35C5.1
See related
AllianceGenome:WB:WBGene00004746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sdc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (11522707..11533450)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein;ZM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Saposin B-type domain-containing protein Neighboring gene Group-specific protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation. Albritton SE, et al. Elife, 2017 May 30. PMID 28562241, Free PMC Article
  2. Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate. Dawes HE, et al. Science, 1999 Jun 11. PMID 10364546
  3. Worm chromosomes call for recognition! Rattner BP, et al. Bioessays, 2004 Jul. PMID 15221851
  4. xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision. Rhind NR, et al. Cell, 1995 Jan 13. PMID 7813020
  5. Genome-wide analysis of condensin binding in Caenorhabditis elegans. Kranz AL, et al. Genome Biol, 2013. PMID 24125077, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in dosage compensation by hypoactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sex determination and dosage compensation protein sdc-2
NP_509924.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11522707..11533450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077523.7 → NP_509924.1  Sex determination and dosage compensation protein sdc-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509924.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBL3
    Conserved Domains (1) summary
    cl26511
    Location:1085 → 1392
    Neuromodulin_N; Gap junction protein N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBL3.1

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