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ttyh-1 Protein tweety homolog 1 [ Caenorhabditis elegans ]

Gene ID: 181328, updated on 4-Jan-2025

Summary

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Official Symbol
ttyh-1
Official Full Name
Protein tweety homolog 1
Primary source
WormBase:WBGene00009632
Locus tag
CELE_F42E11.2
See related
AllianceGenome:WB:WBGene00009632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable intracellularly calcium-gated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including egg-laying apparatus; enteric muscle; excretory cell; nervous system; and rectal gland cell. Orthologous to several human genes including TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ttyh-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (11368717..11374359)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Multidrug resistance protein pgp-3 Neighboring gene P-GlycoProtein related Neighboring gene ncRNA Neighboring gene Brp/Blh family beta-carotene 15,15'-monooxygenase Neighboring gene Troponin I 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables volume-sensitive chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein tweety homolog 1
NP_001379257.1
  • Confirmed by transcript evidence
NP_509903.1
  • Confirmed by transcript evidence
NP_741904.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11368717..11374359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171973.9 → NP_741904.1  Protein tweety homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741904.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20332
    Conserved Domains (1) summary
    cd07912
    Location:1 → 428
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  2. NM_077502.8 → NP_509903.1  Protein tweety homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20332, Q7JM69, Q8MQ53, Q9U3F6
    Conserved Domains (1) summary
    cd07912
    Location:1 → 428
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  3. NM_001392843.1 → NP_001379257.1  Protein tweety homolog 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl12141
    Location:1 → 95
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20332.1

Gene LinkOut

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