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pgp-3 Multidrug resistance protein pgp-3 [ Caenorhabditis elegans ]

Gene ID: 181326, updated on 9-Dec-2024

Summary

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Official Symbol
pgp-3
Official Full Name
Multidrug resistance protein pgp-3
Primary source
WormBase:WBGene00003997
Locus tag
CELE_ZK455.7
See related
AllianceGenome:WB:WBGene00003997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Is expressed in excretory cell; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pgp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (11352156..11357094)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cytoplasmic aconitate hydratase Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene P-GlycoProtein related Neighboring gene ncRNA Neighboring gene Protein tweety homolog 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A C. elegans orphan nuclear receptor contributes to xenobiotic resistance. Lindblom TH, et al. Curr Biol, 2001 Jun 5. PMID 11516648
  2. Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease. Machiela E, et al. Aging Dis, 2021 Oct. PMID 34631219, Free PMC Article
  3. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke CR, et al. J Mol Biol, 1992 Nov 20. PMID 1360540
  4. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks A, et al. EMBO J, 1995 May 1. PMID 7743993, Free PMC Article
  5. An automated system for measuring parameters of nematode sinusoidal movement. Cronin CJ, et al. BMC Genet, 2005 Feb 7. PMID 15698479, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The DeltaF508 mutation causes post-transcriptional destabilization and degradation of PGP-3 in C. elegans epithelial cells.
    Title: The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in response to metal ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stress response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Multidrug resistance protein pgp-3
NP_509901.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11352156..11357094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077500.5 → NP_509901.1  Multidrug resistance protein pgp-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34713, Q20335
    Conserved Domains (3) summary
    cd03249
    Location:1029 → 1266
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:105 → 1264
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:50 → 326
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34713.2

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