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oct-2 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181325, updated on 9-Dec-2024

Summary

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Official Symbol
oct-2
Official Full Name
Major facilitator superfamily (MFS) profile domain-containing protein
Primary source
WormBase:WBGene00003843
Locus tag
CELE_ZK455.8
See related
AllianceGenome:WB:WBGene00003843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A15 (solute carrier family 22 member 15). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See oct-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (11346455..11350247)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Receptor-type guanylate cyclase gcy-9 Neighboring gene ncRNA Neighboring gene Cytoplasmic aconitate hydratase Neighboring gene Multidrug resistance protein pgp-3 Neighboring gene P-GlycoProtein related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries. Papaluca A, et al. Sci Rep, 2016 Oct 27. PMID 27786254, Free PMC Article
  2. Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage. Cheah IK, et al. Free Radic Res, 2013 Dec. PMID 24074059
  3. Acetylcholine. Rand JB. WormBook, 2007 Jan 30. PMID 18050502, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Major facilitator superfamily (MFS) profile domain-containing protein
NP_001024992.2
  • Confirmed by transcript evidence
NP_509899.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11346455..11350247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077498.9 → NP_509899.3  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509899.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23501
    Conserved Domains (1) summary
    cd17317
    Location:281 → 673
    MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily

  2. NM_001029821.6 → NP_001024992.2  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024992.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE82
    Conserved Domains (2) summary
    PRK10077
    Location:144 → 174
    xylE; D-xylose transporter XylE; Provisional
    cd17317
    Location:1 → 385
    MFS_SLC22; Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily
Nucleotide Protein
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