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pssy-1 Phosphatidylserine synthase [ Caenorhabditis elegans ]

Gene ID: 181211, updated on 4-Jan-2025

Summary

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Official Symbol
pssy-1
Official Full Name
Phosphatidylserine synthase
Primary source
WormBase:WBGene00013920
Locus tag
CELE_ZC506.3
See related
AllianceGenome:WB:WBGene00013920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pssy-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (9965592..9968578)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cysteine synthase 1 Neighboring gene alpha-1,2-Mannosidase Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of the Major Phosphatidylserine or Phosphatidylethanolamine Flippases Differentially Affect Phagocytosis. Fazeli G, et al. Front Cell Dev Biol, 2020. PMID 32793595, Free PMC Article
  2. Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Nilsson L, et al. Traffic, 2011 Dec. PMID 21917090
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylserine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phosphatidylserine synthase
NP_509673.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9965592..9968578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077272.7 → NP_509673.1  Phosphatidylserine synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09643
    Conserved Domains (1) summary
    pfam03034
    Location:149 → 424
    PSS; Phosphatidyl serine synthase
Nucleotide Protein
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