mrp-4 Multidrug resistance-associated protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrp-4
Official Full Name: Multidrug resistance-associated protein 1
Primary source: WormBase:WBGene00003410
Locus tag: CELE_F21G4.2
See related: AllianceGenome:WB:WBGene00003410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in lipid transport involved in lipid storage and lysosome organization. Located in endocytic vesicle and gut granule. Is expressed in intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mrp-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (9884274..9889712)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRP-4 localizes to the gut granule membrane, consistent with it playing a direct role in the transport of molecules that compose and/or facilitate the formation of birefringent crystals within the gut granule.
Title: Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation.
MRP-4 localizes to endocytic compartments and its levels are elevated in the absence of CUP-5.
Title: Suppression of the cup-5 mucolipidosis type IV-related lysosomal dysfunction by the inactivation of an ABC transporter in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21G4.2 (e-PCR)
- UniSTS:321386

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport involved in lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lysosome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in gut granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Multidrug resistance-associated protein 1

NP_509658.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9884274..9889712

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077257.6 → NP_509658.1 Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509658.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFP3

Conserved Domains (4) summary

TIGR00957
Location:17 → 1572

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1332 → 1552

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:658 → 862

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

cl00549
Location:346 → 613

ABC_membrane; ABC transporter transmembrane region