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ipla-2 Intracellular phospholipase A2 [ Caenorhabditis elegans ]

Gene ID: 181196, updated on 9-Dec-2024

Summary

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Official Symbol
ipla-2
Official Full Name
Intracellular phospholipase A2
Primary source
WormBase:WBGene00009801
Locus tag
CELE_F47A4.5
See related
AllianceGenome:WB:WBGene00009801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Involved in intestinal lipid catabolic process and response to starvation. Located in cytoplasm. Is expressed in body wall musculature; head neurons; intestine; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ipla-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (9833352..9838039, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mediator of RNA polymerase II transcription subunit 12 Neighboring gene GTPase-activating protein rrc-1 Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Schmeisser S, et al. Cell Rep, 2019 Dec 24. PMID 31875559
  2. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
  3. PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans. Huang WM, et al. Biochem J, 2014 Aug 1. PMID 24854345
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestinal lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Intracellular phospholipase A2
NP_509647.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9833352..9838039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077246.7 → NP_509647.1  Intracellular phospholipase A2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20500
    Conserved Domains (3) summary
    cd07212
    Location:747 → 1045
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA03095
    Location:495 → 677
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:579 → 612
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20500.1

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