U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rrc-1 GTPase-activating protein rrc-1 [ Caenorhabditis elegans ]

Gene ID: 181195, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
rrc-1
Official Full Name
GTPase-activating protein rrc-1
Primary source
WormBase:WBGene00009800
Locus tag
CELE_F47A4.3
See related
AllianceGenome:WB:WBGene00009800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activator activity. Involved in positive regulation of GTPase activity. Is expressed in GLRL; GLRR; coelomocyte; excretory cell; and uterine seam cell. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Orthologous to several human genes including ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rrc-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (9823752..9831288, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Ligand-gated ion channel 50 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 12 Neighboring gene tRNA-Ile Neighboring gene Intracellular phospholipase A2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans. Delawary M, et al. Biochem Biophys Res Commun, 2007 Jun 1. PMID 17434147
  2. The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle. Moody JC, et al. Mol Biol Cell, 2024 Apr 1. PMID 38446619, Free PMC Article
  3. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
  4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GTPase-activating protein rrc-1
NP_001024683.1
  • Confirmed by transcript evidence
NP_001024684.1
  • Confirmed by transcript evidence
NP_001257090.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9823752..9831288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029512.5 → NP_001024683.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20498, Q5WRQ3
    Conserved Domains (3) summary
    cl02563
    Location:41 → 146
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl02570
    Location:276 → 466
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:168 → 238
    SH3; Src Homology 3 domain superfamily

  2. NM_001270161.4 → NP_001257090.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257090.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRH8
    Conserved Domains (3) summary
    cl02563
    Location:41 → 146
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl02570
    Location:276 → 466
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:168 → 238
    SH3; Src Homology 3 domain superfamily

  3. NM_001029513.6 → NP_001024684.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024684.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20498
    Conserved Domains (3) summary
    cl02563
    Location:24 → 129
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl02570
    Location:259 → 449
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:151 → 221
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20498.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools