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nep-22 Neprilysin [ Caenorhabditis elegans ]

Gene ID: 181144, updated on 2-Nov-2024

Summary

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Official Symbol
nep-22
Official Full Name
Neprilysin
Primary source
WormBase:WBGene00020788
Locus tag
CELE_T25B6.2
See related
AllianceGenome:WB:WBGene00020788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Located in membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nep-22 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (9034554..9038547)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene TryThrA_C domain-containing protein Neighboring gene Sodium-dependent transporter snf-12 Neighboring gene RGS domain-containing protein Neighboring gene PR/SET domain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assessment of Caenorhabditis elegans as a model in Haemonchus contortus vaccine research. Geldhof P, et al. Mol Biochem Parasitol, 2007 Apr. PMID 17234278
  2. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
  3. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
  4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neprilysin
NP_509528.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9034554..9038547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077127.5 → NP_509528.1  Neprilysin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22763
    Conserved Domains (2) summary
    cd08662
    Location:83 → 793
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:76 → 795
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version

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