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acs-22 Long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

Gene ID: 181138, updated on 9-Dec-2024

Summary

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Official Symbol
acs-22
Official Full Name
Long-chain-fatty-acid--CoA ligase
Primary source
WormBase:WBGene00017012
Locus tag
CELE_D1009.1
See related
AllianceGenome:WB:WBGene00017012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Located in endoplasmic reticulum. Is expressed in head neurons; hypodermis; intestine; and pharynx. Orthologous to human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acs-22 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (8931179..8939263)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene tRNA-Gln Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Tctex1 domain-containing protein 2 Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Trp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. Kage-Nakadai E, et al. PLoS One, 2010 Jan 25. PMID 20111596, Free PMC Article
  2. Damage on functional state of intestinal barrier by microgravity stress in nematode Caenorhabditis elegans. Liu H, et al. Ecotoxicol Environ Saf, 2019 Nov 15. PMID 31434019
  3. Lactic Acid Bacteria Protects Caenorhabditis elegans from Toxicity of Graphene Oxide by Maintaining Normal Intestinal Permeability under different Genetic Backgrounds. Zhao Y, et al. Sci Rep, 2015 Nov 27. PMID 26611622, Free PMC Article
  4. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. Xu N, et al. J Cell Biol, 2012 Sep 3. PMID 22927462, Free PMC Article
  5. A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans. Li S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261001, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Long-chain-fatty-acid--CoA ligase
NP_001309684.1
  • Confirmed by transcript evidence
NP_001380195.1
  • Confirmed by transcript evidence
NP_509509.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8931179..8939263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077108.6 → NP_509509.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18916
    Conserved Domains (2) summary
    cd05939
    Location:105 → 618
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:49 → 650
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  2. NM_001392815.1 → NP_001380195.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBB2
    Conserved Domains (1) summary
    cd05939
    Location:102 → 615
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

  3. NM_001322629.4 → NP_001309684.1  Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB92
    Conserved Domains (2) summary
    PRK12406
    Location:2 → 505
    PRK12406; long-chain-fatty-acid--CoA ligase; Provisional
    cl17068
    Location:1 → 488
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
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