mec-10 Degenerin mec-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mec-10
Official Full Name: Degenerin mec-10
Primary source: WormBase:WBGene00003174
Locus tag: CELE_F16F9.5
See related: AllianceGenome:WB:WBGene00003174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ligand-gated sodium channel activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in cell body membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 2; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to several human genes including SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mec-10 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 17

Sequence:: Chromosome: X; NC_003284.9 (8465760..8470314, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LSS response was largely abolished by MEC-10 mutations encoded by a touch-insensitive mec-10 allele, providing a correlation between the channel's responses to two different mechanical forces
Title: Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.
MEC-10, but not MEC-6, forms puncta in touch receptor neurites that colocalize with MEC-4 when MEC-4 is overexpressed in the touch receptor neurons
Title: Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.
This study suggested that mutant MEC-10 proteins may affect channel current via MEC-2.
Title: The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons.
MEC-10 protein is asymmetrically distributed within the touch neuron process. It may contribute to only a subset of gentle touch mechanosensory complexes found preferentially at the proximal dendrite.
Title: Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.
harsh touch specifically required the DEG/ENaC proteins MEC-10 and DEGT-1 (F25D1.4), which represent putative components of a harsh touch mechanotransduction complex; responses to cold required the TRPA-1 channel and were MEC-10 and DEGT-1 independent
Title: Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F16F9.5 (e-PCR)
- UniSTS:314049

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mechanosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Degenerin mec-10

NP_509438.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8465760..8470314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077037.7 → NP_509438.1 Degenerin mec-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509438.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34886, P37087

Conserved Domains (2) summary

TIGR00867
Location:99 → 696

deg-1; degenerin

cl02990
Location:88 → 723

ASC; Amiloride-sensitive sodium channel