tth-1 Thymosin beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tth-1
Official Full Name: Thymosin beta
Primary source: WormBase:WBGene00006649
Locus tag: CELE_F08F1.8
See related: AllianceGenome:WB:WBGene00006649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization. Predicted to be located in anchoring junction; cell cortex; and cytoskeleton. Predicted to be active in cytosol. Is expressed in gonad; intestine; nervous system; oocyte; and terminal bulb. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tth-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (8422480..8423731, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the activity of tetraThymosinbeta is of crucial importance at specific developmental stages requiring actin polymerization.
Title: TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08F1.8 (e-PCR)
- UniSTS:319218

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Thymosin beta

NP_509430.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8422480..8423731 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077029.5 → NP_509430.1 Thymosin beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509430.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17389

Conserved Domains (2) summary

smart00152
Location:51 → 87

THY; Thymosin beta actin-binding motif

pfam01290
Location:22 → 47

Thymosin; Thymosin beta-4 family