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cca-1 Voltage-dependent T-type calcium channel subunit alpha [ Caenorhabditis elegans ]

Gene ID: 181045, updated on 9-Dec-2024

Summary

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Official Symbol
cca-1
Official Full Name
Voltage-dependent T-type calcium channel subunit alpha
Primary source
WormBase:WBGene00000367
Locus tag
CELE_C54D2.5
See related
AllianceGenome:WB:WBGene00000367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of nematode pharyngeal pumping. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in alimentary muscle; body wall musculature; distal tip cell; intestine; and nervous system. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42; childhood absence epilepsy; primary hyperaldosteronism; and schizophrenia. Orthologous to several human genes including CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cca-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
31
Sequence:
Chromosome: X; NC_003284.9 (7847678..7875954, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene EB domain-containing protein Neighboring gene ncRNA Neighboring gene DUF281 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF4440 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans. Pandey R, et al. Seizure, 2010 Sep. PMID 20598917
  2. Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels. Zang KE, et al. Elife, 2017 Feb 6. PMID 28165324, Free PMC Article
  3. Sexually Dimorphic Neurotransmitter Release at the Neuromuscular Junction in Adult Caenorhabditis elegans. Yan Z, et al. Front Mol Neurosci, 2021. PMID 35173578, Free PMC Article
  4. Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD. Nicoletti M, et al. PLoS One, 2019. PMID 31260485, Free PMC Article
  5. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Kwok TC, et al. Nature, 2006 May 4. PMID 16672971

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that T-type calcium channels are critical regulators of a Caenorhabditis elegans serotonergic circuit and demonstrate a mechanism in which T-type channels functionally gate inhibitory modulation in vivo.
    Title: Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels.
  2. We conclude that the CCA-1 T-type calcium channel boosts the excitatory effect of synaptic input, allowing for reliable and rapid depolarization and contraction of the pharyngeal muscle.
    Title: The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission.
  3. Our results suggest that CCA-1's role is to accelerate the action potential upstroke in the pharyngeal muscle in response to excitatory inputs.
    Title: CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables low voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Voltage-dependent T-type calcium channel subunit alpha
NP_001367690.1
  • Confirmed by transcript evidence
NP_001367691.1
  • Confirmed by transcript evidence
NP_001367692.1
  • Confirmed by transcript evidence
NP_001368577.1
  • Confirmed by transcript evidence
NP_001379830.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7847678..7875954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381031.2 → NP_001367690.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z002
    Conserved Domains (1) summary
    pfam00520
    Location:659 → 890
    Ion_trans; Ion transport protein

  2. NM_001381028.1 → NP_001367692.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZR6
    Conserved Domains (1) summary
    pfam00520
    Location:659 → 897
    Ion_trans; Ion transport protein

  3. NM_001381030.1 → NP_001367691.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z003
    Conserved Domains (1) summary
    pfam00520
    Location:1159 → 1430
    Ion_trans; Ion transport protein

  4. NM_001392802.1 → NP_001379830.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBS2
    Conserved Domains (1) summary
    pfam00520
    Location:659 → 890
    Ion_trans; Ion transport protein

  5. NM_001381029.1 → NP_001368577.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASP4
    Conserved Domains (1) summary
    pfam00520
    Location:659 → 897
    Ion_trans; Ion transport protein
Nucleotide Protein
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