ceh-14 LIM/homeobox protein ceh-14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-14
Official Full Name: LIM/homeobox protein ceh-14
Primary source: WormBase:WBGene00000438
Locus tag: CELE_F46C8.5
See related: AllianceGenome:WB:WBGene00000438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in nucleus. Is expressed in several structures, including anal region; gonad; hypodermis; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to several human genes including LHX3 (LIM homeobox 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ceh-14 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (7527769..7532732, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18, and determines the fate of AFD neurons as terminal selector genes at the final step of cell specification.
Title: Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans.
loss of a LIM domain in the ceh-14(ch2) allele causes a partial loss-of-function phenotype
Title: The LIM homeobox gene ceh-14 is required for phasmid function and neurite outgrowth.
Results indicate that MAB-18 and CEH-14 interact to repress col-43 expression in sth-1-expressing tissues.
Title: The homeoproteins MAB-18 and CEH-14 insulate the dauer collagen gene col-43 from activation by the adjacent promoter of the Spermatheca gene sth-1 in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F46C8.5 (e-PCR)
- UniSTS:314357

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LIM/homeobox protein ceh-14

NP_509273.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7527769..7532732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076872.4 → NP_509273.1 LIM/homeobox protein ceh-14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509273.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P20271, Q9NBV6

Conserved Domains (4) summary

cd09376
Location:107 → 163

LIM2_Lhx3_Lhx4; The second LIM domain of Lhx3-Lhx4 family

COG5576
Location:172 → 295

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:183 → 236

Homeobox; Homeobox domain

pfam00412
Location:48 → 103

LIM; LIM domain