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sng-1 Synaptogyrin homolog 1 [ Caenorhabditis elegans ]

Gene ID: 180995, updated on 4-Jan-2025

Summary

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Official Symbol
sng-1
Official Full Name
Synaptogyrin homolog 1
Primary source
WormBase:WBGene00004912
Locus tag
CELE_T08A9.3
See related
AllianceGenome:WB:WBGene00004912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in regulation of exocytosis and synaptic vesicle transport. Located in synaptic vesicle. Is expressed in muscle cell and nervous system. Orthologous to several human genes including SYNGR1 (synaptogyrin 1); SYNGR2 (synaptogyrin 2); and SYNGR4 (synaptogyrin 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sng-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (7327601..7329705)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein Neighboring gene TransThyretin-Related family domain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved mechanism of synaptogyrin localization. Zhao H, et al. Mol Biol Cell, 2001 Aug. PMID 11514616, Free PMC Article
  2. Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans. Abraham C, et al. Proc Natl Acad Sci U S A, 2006 May 23. PMID 16698939, Free PMC Article
  3. Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans. Abraham C, et al. Neuroscience, 2011 Sep 8. PMID 21689733
  4. The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission in Caenorhabditis elegans. Pannone L, et al. Front Mol Neurosci, 2023. PMID 37324589, Free PMC Article
  5. Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans. Hellman AB, et al. PLoS One, 2011. PMID 21915351, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these observations assign a distinct modulatory and redundant neuronal function to synaptogyrin.
    Title: Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in regulation of exocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Synaptogyrin homolog 1
NP_509239.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7327601..7329705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076838.6 → NP_509239.1  Synaptogyrin homolog 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76735, Q22340
    Conserved Domains (1) summary
    pfam01284
    Location:21 → 169
    MARVEL; Membrane-associating domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76735.1

Gene LinkOut

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