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kqt-1 Potassium voltage-gated channel subfamily KQT member 5 [ Caenorhabditis elegans ]

Gene ID: 180933, updated on 4-Jan-2025

Summary

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Official Symbol
kqt-1
Official Full Name
Potassium voltage-gated channel subfamily KQT member 5
Primary source
WormBase:WBGene00002233
Locus tag
CELE_C25B8.1
See related
AllianceGenome:WB:WBGene00002233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; intracellular signal transduction; and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in head neurons; pharyngeal muscle cell; and touch receptor neurons. Used to study developmental and epileptic encephalopathy and long QT syndrome. Human ortholog(s) of this gene implicated in auditory system disease (multiple); autistic disorder; autosomal dominant intellectual developmental disorder 46; and electroclinical syndrome (multiple). Orthologous to several human genes including KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kqt-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (6619012..6627995)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cathepsin B-like cysteine proteinase 6 Neighboring gene Claudin domain-containing protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. Wei AD, et al. J Biol Chem, 2005 Jun 3. PMID 15797864
  2. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
  3. Potassium channels in C. elegans. Salkoff L, et al. WormBook, 2005 Dec 30. PMID 18050399, Free PMC Article
  4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  5. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Potassium voltage-gated channel subfamily KQT member 5
NP_741819.1
  • Confirmed by transcript evidence
NP_741820.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6619012..6627995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171709.6 → NP_741819.1  Potassium voltage-gated channel subfamily KQT member 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQC5
    Conserved Domains (3) summary
    pfam00520
    Location:173 → 379
    Ion_trans; Ion transport protein
    pfam03520
    Location:540 → 651
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:297 → 371
    Ion_trans_2; Ion channel

  2. NM_171710.7 → NP_741820.1  Potassium voltage-gated channel subfamily KQT member 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDN5
    Conserved Domains (3) summary
    pfam00520
    Location:125 → 331
    Ion_trans; Ion transport protein
    pfam03520
    Location:492 → 603
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:249 → 323
    Ion_trans_2; Ion channel
Nucleotide Protein
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