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cdf-1 Cation diffusion facilitator family protein 1;Zinc transporter 1 [ Caenorhabditis elegans ]

Gene ID: 180923, updated on 4-Jan-2025

Summary

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Official Symbol
cdf-1
Official Full Name
Cation diffusion facilitator family protein 1;Zinc transporter 1
Primary source
WormBase:WBGene00000393
Locus tag
CELE_C15B12.7
See related
AllianceGenome:WB:WBGene00000393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in cellular response to zinc ion; positive regulation of Ras protein signal transduction; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including P5.p hermaphrodite; P6.p hermaphrodite; P7.p hermaphrodite; rectal valve cell; and vulval cell. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cdf-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (6499916..6505133, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ACT1-like protein Neighboring gene Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Transthyretin-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans. Sharma AK, et al. Front Physiol, 2023. PMID 37822680, Free PMC Article
  2. Cation diffusion facilitator proteins modulate Raf-1 activity. Jirakulaporn T, et al. J Biol Chem, 2004 Jun 25. PMID 15096503
  3. ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. Roh HC, et al. PLoS Genet, 2013 May. PMID 23717214, Free PMC Article
  4. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Bruinsma JJ, et al. Genetics, 2008 Jun. PMID 18505880, Free PMC Article
  5. SLC30A10: A novel manganese transporter. Chen P, et al. Worm, 2015 Jul-Sep. PMID 26430566, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detoxification of zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in zinc ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cation diffusion facilitator family protein 1;Zinc transporter 1
NP_001300317.1
  • Confirmed by transcript evidence
NP_509095.2
  • Confirmed by transcript evidence
NP_509096.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6499916..6505133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076694.7 → NP_509095.2  Cation diffusion facilitator family protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18009, Q95QW4
    Conserved Domains (1) summary
    COG1230
    Location:93 → 510
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

  2. NM_001313388.6 → NP_001300317.1  Zinc transporter 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18009, Q95QW4
    UniProtKB/TrEMBL
    A0A0K3ASM2
    Conserved Domains (2) summary
    COG1230
    Location:61 → 478
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    pfam01545
    Location:73 → 185
    Cation_efflux; Cation efflux family

  3. NM_076695.6 → NP_509096.2  Cation diffusion facilitator family protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18009, Q95QW4
    Conserved Domains (1) summary
    COG1230
    Location:135 → 552
    CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
Nucleotide Protein
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