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hsp-3 Heat shock 70 kDa protein C [ Caenorhabditis elegans ]

Gene ID: 180880, updated on 4-Jan-2025

Summary

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Official Symbol
hsp-3
Official Full Name
Heat shock 70 kDa protein C
Primary source
WormBase:WBGene00002007
Locus tag
CELE_C15H9.6
See related
AllianceGenome:WB:WBGene00002007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Predicted to be part of endoplasmic reticulum chaperone complex. Predicted to be active in endoplasmic reticulum lumen; membrane; and nucleus. Is expressed in several structures, including germ line; intestine; pharyngeal gland cell; pharyngeal-intestinal valve; and tail. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See hsp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (6089033..6091785, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Transposase Neighboring gene GOST seven transmembrane domain-containing protein Neighboring gene Transmembrane and coiled-coil domains protein 2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes. Heschl MF, et al. J Mol Evol, 1990 Jul. PMID 2116528
  2. To UPR… and beyond! A new role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Lamitina T, et al. Virulence, 2012 May 1. PMID 22665168, Free PMC Article
  3. Construction of a bicistronic vector for the co-expression of two genes in Caenorhabditis elegans using a newly identified IRES. Li D, et al. Biotechniques, 2012 Mar. PMID 22401550
  4. Characterization of the hsp70 multigene family of Caenorhabditis elegans. Heschl MF, et al. DNA, 1989 May. PMID 2766926
  5. Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans. Avila DS, et al. BMC Pharmacol Toxicol, 2016 Nov 2. PMID 27802836, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrated a specific role for hsp-3 in the regulation of nlp-29 after infection that is not shared with hsp-4.
    Title: A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis.
  2. BiP(HSP-3) play important roles in the developmental growth and function of intestinal cells.
    Title: ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in IRE1-mediated unfolded protein response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of endoplasmic reticulum chaperone complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Heat shock 70 kDa protein C
NP_001294778.1
  • Confirmed by transcript evidence
NP_001370435.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6089033..6091785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383595.2 → NP_001370435.1  Heat shock 70 kDa protein C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27420, Q7JNW0
    Conserved Domains (1) summary
    PTZ00009
    Location:32 → 648
    PTZ00009; heat shock 70 kDa protein; Provisional

  2. NM_001307849.4 → NP_001294778.1  Heat shock 70 kDa protein C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJ24
    Conserved Domains (1) summary
    PTZ00009
    Location:1 → 312
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27420.2

Gene LinkOut

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