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tbc-16 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180856, updated on 2-Nov-2024

Summary

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Official Symbol
tbc-16
Official Full Name
Rab-GAP TBC domain-containing protein
Primary source
WormBase:WBGene00018639
Locus tag
CELE_F49E10.1
See related
AllianceGenome:WB:WBGene00018639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Predicted to be active in early endosome. Is expressed in nervous system. Orthologous to human TBC1D16 (TBC1 domain family member 16). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbc-16 in Genome Data Viewer
Location:
chromosome: X
Exon count:
17
Sequence:
Chromosome: X; NC_003284.9 (5897338..5902157)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Carotenoid oxygenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rab-GAP TBC domain-containing protein
NP_508988.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5897338..5902157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076587.7 → NP_508988.3  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508988.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20600
    Conserved Domains (2) summary
    smart00164
    Location:415 → 644
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam12068
    Location:32 → 136
    DUF3548; Domain of unknown function (DUF3548)
Nucleotide Protein
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