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gnrr-4 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180841, updated on 4-Jan-2025

Summary

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Official Symbol
gnrr-4
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00016570
Locus tag
CELE_C41G11.4
See related
AllianceGenome:WB:WBGene00016570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypotrichosis 8; and respiratory allergy. Orthologous to several human genes including F2RL3 (F2R like thrombin or trypsin receptor 3); F2RL1 (F2R like trypsin receptor 1); and GPR17 (G protein-coupled receptor 17). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See gnrr-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (5738756..5743309, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001359929.1
  • Confirmed by transcript evidence
NP_001360691.1
  • Confirmed by transcript evidence
NP_741798.1
  • Confirmed by transcript evidence
NP_741799.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5738756..5743309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171692.7 → NP_741798.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18564
    Conserved Domains (2) summary
    cd14964
    Location:25 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25 → 179
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_171954.7 → NP_741799.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ99
    Conserved Domains (2) summary
    cd14964
    Location:25 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25 → 179
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001373309.4 → NP_001359929.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZA0
    Conserved Domains (2) summary
    cd14964
    Location:25 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25 → 179
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_001373308.3 → NP_001360691.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILV8
    Conserved Domains (2) summary
    cd14964
    Location:25 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25 → 179
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
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