U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mec-2 Band 7 domain-containing protein;Mechanosensory protein 2 [ Caenorhabditis elegans ]

Gene ID: 180826, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mec-2
Official Full Name
Band 7 domain-containing protein;Mechanosensory protein 2
Primary source
WormBase:WBGene00003166
Locus tag
CELE_F14D12.4
See related
AllianceGenome:WB:WBGene00003166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cholesterol binding activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of touch; positive regulation of detection of mechanical stimulus involved in sensory perception of touch; and positive regulation of mechanosensory behavior. Located in neuron projection membrane. Is expressed in nervous system. Used to study nephrotic syndrome. Orthologous to human STOM (stomatin). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mec-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (5567754..5590830)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SAP30_Sin3_bdg domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LIM domain-containing protein unc-97 Neighboring gene STAS domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Stiffened lipid platforms at molecular force foci. Anishkin A, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23476066, Free PMC Article
  2. A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing. Sanfeliu-Cerdán N, et al. Nat Cell Biol, 2023 Nov. PMID 37857834, Free PMC Article
  3. Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans. Calixto A, et al. Nat Methods, 2010 May. PMID 20364149, Free PMC Article
  4. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Huber TB, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17079490, Free PMC Article
  5. Genetic screens identified dual roles of microtubule-associated serine threonine kinase and CREB within a single thermosensory neuron in the regulation of Caenorhabditis elegans thermotaxis behavior. Nakano S, et al. G3 (Bethesda), 2022 Nov 4. PMID 36102820, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing.
    Title: Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing.
  2. Ubiquitin ligase Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers. Ubiquitylation of one MEC-2 site, K301, do not only target MEC-2 for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.
    Title: The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
  3. the carboxyl terminus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate cholesterol binding and contribute to ion channel activity.
    Title: A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.
  4. [review] Similarly to stomatins from other species, C. elegans counterparts may also be membrane proteins with intracellular amino- and carboxyl-terminals.
    Title: Stomatin-domain proteins.
  5. MEC-2 with MEC-6 increase open probability of ENaC (constitutively active MEC-4/MEC-10 in Xenopus oocytes), decrease the efficiency of Ca2+ block. Its palmitoylation and cholesterol-binding activity are required for channel activation
    Title: MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity.
  6. MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane
    Title: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mechanosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of detection of mechanical stimulus involved in sensory perception of touch IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mechanosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Band 7 domain-containing protein;Mechanosensory protein 2
NP_001024566.1
  • Confirmed by transcript evidence
NP_001024567.1
  • Confirmed by transcript evidence
NP_001355457.1
  • Confirmed by transcript evidence
NP_001355458.1
  • Confirmed by transcript evidence
NP_001355459.1
  • Confirmed by transcript evidence
NP_001355460.1
  • Confirmed by transcript evidence
NP_001355478.1
  • Confirmed by transcript evidence
NP_001355479.1
  • Confirmed by transcript evidence
NP_001355480.1
  • Confirmed by transcript evidence
NP_001368710.1
  • Confirmed by transcript evidence
NP_001368712.1
  • Confirmed by transcript evidence
NP_001368713.1
  • Confirmed by transcript evidence
NP_001368714.1
  • Confirmed by transcript evidence
NP_001368715.1
  • Confirmed by transcript evidence
NP_001368716.1
  • Confirmed by transcript evidence
NP_001368717.1
  • Confirmed by transcript evidence
NP_741797.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5567754..5590830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001368504.4 → NP_001355460.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DQJ7
    Conserved Domains (1) summary
    cd03403
    Location:78 → 279
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_001368508.5 → NP_001355458.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E532
    Conserved Domains (1) summary
    cd03403
    Location:101 → 302
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. NM_001380971.2 → NP_001368710.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DVR7
    Conserved Domains (2) summary
    PTZ00121
    Location:512 → 854
    PTZ00121; MAEBL; Provisional
    cd03403
    Location:101 → 302
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  4. NM_001368507.2 → NP_001355459.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E8U1
    Conserved Domains (1) summary
    cd03403
    Location:101 → 302
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  5. NM_001368505.3 → NP_001355457.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E3V6
    Conserved Domains (1) summary
    cd03403
    Location:101 → 302
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  6. NM_171691.6 → NP_741797.1  Mechanosensory protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741797.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27433
    Conserved Domains (2) summary
    smart00244
    Location:139 → 291
    PHB; prohibitin homologues
    cd03403
    Location:160 → 361
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  7. NM_001380972.1 → NP_001368712.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E057
    Conserved Domains (2) summary
    PTZ00121
    Location:571 → 913
    PTZ00121; MAEBL; Provisional
    cd03403
    Location:160 → 361
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  8. NM_001380973.1 → NP_001368715.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E9Z8
    Conserved Domains (1) summary
    cd03403
    Location:160 → 361
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  9. NM_001029395.4 → NP_001024566.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ74
    Conserved Domains (1) summary
    cd03403
    Location:160 → 361
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  10. NM_001368514.4 → NP_001355480.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DQN5
    Conserved Domains (1) summary
    cd03403
    Location:93 → 294
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  11. NM_001368511.3 → NP_001355478.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E553
    Conserved Domains (1) summary
    cd03403
    Location:93 → 294
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  12. NM_001380974.1 → NP_001368713.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DVV1
    Conserved Domains (2) summary
    PTZ00121
    Location:504 → 846
    PTZ00121; MAEBL; Provisional
    cd03403
    Location:93 → 294
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  13. NM_001380975.1 → NP_001368716.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E520
    Conserved Domains (1) summary
    cd03403
    Location:93 → 294
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  14. NM_001029396.4 → NP_001024567.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ92
    Conserved Domains (1) summary
    cd03403
    Location:85 → 286
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  15. NM_001368515.4 → NP_001355479.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E8U8
    Conserved Domains (1) summary
    cd03403
    Location:85 → 286
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  16. NM_001380976.1 → NP_001368714.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E3Y0
    Conserved Domains (2) summary
    PTZ00121
    Location:496 → 838
    PTZ00121; MAEBL; Provisional
    cd03403
    Location:85 → 286
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  17. NM_001380977.1 → NP_001368717.1  Band 7 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DR76
    Conserved Domains (1) summary
    cd03403
    Location:85 → 286
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27433.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools