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itm-2 Integral membrane protein 2 [ Caenorhabditis elegans ]

Gene ID: 180816, updated on 9-Dec-2024

Summary

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Official Symbol
itm-2
Official Full Name
Integral membrane protein 2
Primary source
WormBase:WBGene00016106
Locus tag
CELE_C25F6.7
See related
AllianceGenome:WB:WBGene00016106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to several human genes including ITM2B (integral membrane protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See itm-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (5445163..5448085)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of amyloid precursor protein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Integral membrane protein 2
NP_741791.2
  • Confirmed by transcript evidence
NP_741792.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5445163..5448085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171952.5 → NP_741792.2  Integral membrane protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741792.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQC3
    Conserved Domains (1) summary
    smart01039
    Location:170 → 270
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

  2. NM_171687.6 → NP_741791.2  Integral membrane protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741791.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZ11
    Conserved Domains (1) summary
    smart01039
    Location:171 → 271
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
Nucleotide Protein
Heading Accession and Version

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