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sek-4 mitogen-activated protein kinase kinase [ Caenorhabditis elegans ]

Gene ID: 180811, updated on 9-Dec-2024

Summary

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Official Symbol
sek-4
Official Full Name
mitogen-activated protein kinase kinase
Primary source
WormBase:WBGene00018035
Locus tag
CELE_F35C8.2
See related
AllianceGenome:WB:WBGene00018035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable MAP kinase kinase activity. Predicted to be involved in stress-activated MAPK cascade. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sek-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (5375059..5377042)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Dual specificity mitogen-activated protein kinase kinase jkk-1 Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene mitogen-activated protein kinase kinase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
  2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase
NP_508915.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5375059..5377042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076514.8 → NP_508915.3  mitogen-activated protein kinase kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508915.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58AU8
    Conserved Domains (1) summary
    cl21453
    Location:57 → 324
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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