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pnk-4 4'-phosphopantetheine phosphatase [ Caenorhabditis elegans ]

Gene ID: 180779, updated on 9-Dec-2024

Summary

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Official Symbol
pnk-4
Official Full Name
4'-phosphopantetheine phosphatase
Primary source
WormBase:WBGene00006862
Locus tag
CELE_C42D8.3
See related
AllianceGenome:WB:WBGene00006862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and tail. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pnk-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (5087841..5092538)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein;ETS domain-containing transcription factor ets-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene Inactive angiotensin-converting enzyme-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of regions of the Caenorhabditis elegans X chromosome containing vitellogenin genes. Heine U, et al. J Mol Biol, 1986 Apr 5. PMID 3735423
  2. Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma. Trimmer KA, et al. Cell Rep, 2023 Jun 27. PMID 37227820, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
4'-phosphopantetheine phosphatase
NP_508866.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5087841..5092538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076465.5 → NP_508866.1  4'-phosphopantetheine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18580
    Conserved Domains (2) summary
    pfam03630
    Location:23 → 345
    Fumble; Fumble
    cl15397
    Location:422 → 739
    DUF89; Protein of unknown function DUF89
Nucleotide Protein
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