npr-1 Neuropeptide receptor npr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npr-1
Official Full Name: Neuropeptide receptor npr-1
Primary source: WormBase:WBGene00003807
Locus tag: CELE_C39E6.6
See related: AllianceGenome:WB:WBGene00003807
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables neuropeptide receptor activity. Involved in several processes, including behavioral response to ethanol; neuropeptide signaling pathway; and thermotaxis. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in excretory system; neurons; pharyngeal muscle cell; and preanal ganglion. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (4767152..4769985, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
Title: Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
Measuring Caenorhabditis elegans Spatial Foraging and Food Intake Using Bioluminescent Bacteria.
Title: Measuring Caenorhabditis elegans Spatial Foraging and Food Intake Using Bioluminescent Bacteria.
NPR-1 signaling is required for a flight response that elicits pathogen aversion
Title: Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling.
our analysis suggests that the FLP-18/NPR-1/NPR-4 signaling is a pivotal point in the regulation of reversal length under varied genetic and environmental conditions
Title: FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length in Caenorhabditis elegans.
We found that guanylyl cyclases GCY-5 and GCY-22 and neuropeptide receptor NPR-1 act antagonistically to regulate SOD-1 expression in the gustatory neuron ASER.
Title: Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis.
npr-1 allows the invertebrate immune system to produce highly specialized and potentially opposing immune responses
Title: Contrasting invertebrate immune defense behaviors caused by a single gene, the Caenorhabditis elegans neuropeptide receptor gene npr-1.
The effects of food on adaptation are affected by neuropeptide signaling; the neuropeptide receptors NPR-1 and NPR-2 act to increase adaptation off food.
Title: Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans.
OCR-2 and NPR-1 likely act via a calcium-dependent but MEF-2- and DAF-16-independent pathway...sensory- and circuit-mediated regulation of chemoreceptor genes via multiple pathways .
Title: Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs.
These results suggest that variation in npr-1 has broad pleiotropic effects mediated by altered exposure to bacterial food.
Title: A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology.
This study demonistrated that NPR-1 regulate the circuit mechanism for behavioral quiescence in C. elegans.
Title: Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C39E6.6 (e-PCR)
- UniSTS:313836

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Neuropeptide receptor npr-1

NP_508816.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4767152..4769985 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076415.6 → NP_508816.1 Neuropeptide receptor npr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508816.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18534

Conserved Domains (1) summary

cd15203
Location:27 → 351

7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors