atg-16.1 Autophagic-related protein 16.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atg-16.1
Official Full Name: Autophagic-related protein 16.1
Primary source: WormBase:WBGene00017178
Locus tag: CELE_F02E8.5
See related: AllianceGenome:WB:WBGene00017178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-membrane adaptor activity. Involved in aggrephagy. Located in cytoplasm. Is expressed in several structures, including alimentary muscle; body wall musculature; head mesodermal cell; intestine; and rectal gland cell. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to several human genes including ATG16L1 (autophagy related 16 like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atg-16.1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (4459603..4462465, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans ATG-16s are involved in specifying LGG-1 puncta formation; the two ATG-16 homologs have partially redundant yet distinct functions in the aggrephagy pathway.
Title: The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F02E8.5 (e-PCR)
- UniSTS:309559

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aggrephagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Atg12-Atg5-Atg16 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Autophagic-related protein 16.1

NP_508768.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4459603..4462465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076367.6 → NP_508768.2 Autophagic-related protein 16.1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19124

Conserved Domains (4) summary

COG3883
Location:126 → 220

CwlO1; Uncharacterized N-terminal domain of peptidoglycan hydrolase CwlO [Function unknown]

cd00200
Location:235 → 527

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:246 → 283

7WD40; WD40 repeat [structural motif]

pfam08614
Location:26 → 155

ATG16; Autophagy protein 16 (ATG16)