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mec-18 AMP-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180701, updated on 2-Nov-2024

Summary

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Official Symbol
mec-18
Official Full Name
AMP-binding domain-containing protein
Primary source
WormBase:WBGene00003179
Locus tag
CELE_C52B9.9
See related
AllianceGenome:WB:WBGene00003179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable CoA-ligase activity. Involved in detection of mechanical stimulus involved in sensory perception of touch and mechanosensory behavior. Located in neuron projection and neuronal cell body. Is expressed in PLML and PLMR. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mec-18 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (4271165..4274216, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GOST seven transmembrane domain-containing protein Neighboring gene ncRNA Neighboring gene Tubulin-specific chaperone cofactor E-like protein Neighboring gene Uncharacterized protein Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene ETS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans. Schaefer AM, et al. Neuron, 2000 May. PMID 10839354
  2. The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur DS, et al. Nature, 2002 Dec 12. PMID 12478294
  3. MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity. Zhang Y, et al. Mech Dev, 2002 Nov. PMID 12385749
  4. Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Chalfie M, et al. Science, 1989 Feb 24. PMID 2646709
  5. The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Qin H, et al. Dev Biol, 2004 Jun 1. PMID 15136141

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CoA-ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus involved in sensory perception of touch IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mechanosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AMP-binding domain-containing protein
NP_508731.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4271165..4274216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076330.8 → NP_508731.3  AMP-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508731.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45873
    Conserved Domains (2) summary
    COG0318
    Location:12 → 585
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    cl17068
    Location:35 → 579
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
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