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vha-12 V-type proton ATPase subunit B 1 [ Caenorhabditis elegans ]

Gene ID: 180692, updated on 9-Dec-2024

Summary

Official Symbol
vha-12
Official Full Name
V-type proton ATPase subunit B 1
Primary source
WormBase:WBGene00006921
Locus tag
CELE_F20B6.2
See related
AllianceGenome:WB:WBGene00006921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including positive regulation of apoptotic process involved in development; positive regulation of neurotransmitter secretion; and regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Is expressed in several structures, including excretory system; hypodermal cell; intestine; pharynx; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to several human genes including ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See vha-12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (4191094..4193144)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MD-2-related lipid-recognition domain-containing protein Neighboring gene ncRNA Neighboring gene Multidrug resistance-associated protein lethal(2)03659 Neighboring gene Envelope glycoprotein UL132 Neighboring gene Serine/arginine repetitive matrix protein 2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
enables proton-transporting ATPase activity, rotational mechanism NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy coupled proton transmembrane transport, against electrochemical gradient NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of intracellular pH IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of syncytium formation by plasma membrane fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
V-type proton ATPase subunit B 1
NP_508711.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4191094..4193144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076310.8NP_508711.1  V-type proton ATPase subunit B 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508711.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19626
    Conserved Domains (4) summary
    cd01135
    Location:100381
    V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...
    TIGR01040
    Location:29489
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
    pfam00306
    Location:397483
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:3298
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain