lin-18 Inactive tyrosine-protein kinase RYK [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-18
Official Full Name: Inactive tyrosine-protein kinase RYK
Primary source: WormBase:WBGene00003007
Locus tag: CELE_C16B8.1
See related: AllianceGenome:WB:WBGene00003007
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and protein kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; axis specification; and positive regulation of axon guidance. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in body wall musculature; neurons; vulva; and vulval precursor cell. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lin-18 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (3958552..3961907)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ryk-intracellular domain fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished beta-catenin protection of mutant htt striatal cells against cell death
Title: The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Release of LIN-18ICD by cleavage at the membrane is not the main mechanism of LIN-18 signaling in vulval cells. results suggest LIN-18 intracellular domain interacts with Wnt pathway and a 14-3-3 protein and likely plays a minor role in LIN-18 signaling
Title: Function of the Ryk intracellular domain in C. elegans vulval development.
In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
ceMIB (Caenorhabditis elegans Mindbomb/Y47D3A.22) plays a role in the regulation of C. elegans Wnt/RYK (lin-18) /TCF signaling.
Title: Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
LIN-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors. Members of this family have nonactive kinase domains
Title: C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.
lin-17 (Frizzled type Wnt receptor) and lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva.
Title: lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C16B8.1 (e-PCR)
- UniSTS:308574

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in asymmetric protein localization involved in cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of anatomical structure orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of anatomical structure orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in polarity specification of anterior/posterior axis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of proximal/distal axis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polarity specification of proximal/distal axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of asymmetric cell division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inactive tyrosine-protein kinase RYK

NP_508684.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3958552..3961907

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076283.7 → NP_508684.4 Inactive tyrosine-protein kinase RYK [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508684.4

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGT9

Conserved Domains (3) summary

smart00469
Location:19 → 149

WIF; Wnt-inhibitory factor-1 like domain

cd05043
Location:274 → 579

PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

pfam07714
Location:289 → 572

Pkinase_Tyr; Protein tyrosine kinase