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C18B2.4 GRAM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180652, updated on 9-Dec-2024

Summary

Official Symbol
C18B2.4
Official Full Name
GRAM domain-containing protein
Primary source
WormBase:WBGene00015955
Locus tag
CELE_C18B2.4
See related
AllianceGenome:WB:WBGene00015955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to several human genes including WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See C18B2.4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (3604291..3605741, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene G domain-containing protein Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
GRAM domain-containing protein
NP_508620.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3604291..3605741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076219.8NP_508620.1  GRAM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508620.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18075
    Conserved Domains (2) summary
    cd13214
    Location:29131
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam09770
    Location:196295
    PAT1; Topoisomerase II-associated protein PAT1