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sorf-1 Suppressor of organelle fusion 1 [ Caenorhabditis elegans ]

Gene ID: 180626, updated on 9-Dec-2024

Summary

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Official Symbol
sorf-1
Official Full Name
Suppressor of organelle fusion 1
Primary source
WormBase:WBGene00022769
Locus tag
CELE_ZK563.5
See related
AllianceGenome:WB:WBGene00022769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in organelle fusion and positive regulation of early endosome to late endosome transport. Located in early endosome and late endosome. Orthologous to human WDR91 (WD repeat domain 91). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sorf-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (3376841..3379248, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sodium-dependent phosphate transport protein 2B Neighboring gene CLaudin-like in Caenorhabditis Neighboring gene ncRNA Neighboring gene Apyrase Neighboring gene Putative acid phosphatase 1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. Liu K, et al. J Cell Biol, 2016 Jan 18. PMID 26783301, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SORF-1 and SORF-2 are essential for appropriate maintenance of PtdIns3P levels in early-to-late endosome conversion
    Title: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol 3-kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of early endosome to late endosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Suppressor of organelle fusion 1
NP_508584.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3376841..3379248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076183.9 → NP_508584.3  Suppressor of organelle fusion 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508584.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23533
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23533.3

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