rgl-1 Ral guanine nucleotide dissociation stimulator-like 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rgl-1
Official Full Name: Ral guanine nucleotide dissociation stimulator-like 1
Primary source: WormBase:WBGene00017891
Locus tag: CELE_F28B4.2
See related: AllianceGenome:WB:WBGene00017891
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in epidermal growth factor receptor signaling pathway and positive regulation of vulval development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including coelomocyte; excretory cell; hypodermis; reproductive system; and somatic cell. Orthologous to several human genes including RGL1 (ral guanine nucleotide dissociation stimulator like 1) and RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rgl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (3210470..3220367, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.
Title: Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28B4.2 (e-PCR)
- UniSTS:310000

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ral guanine nucleotide dissociation stimulator-like 1

NP_001123140.1

Partially confirmed by transcript evidence

NP_508550.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3210470..3220367 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076149.8 → NP_508550.1 Ral guanine nucleotide dissociation stimulator-like 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508550.1

Status: REVIEWED

UniProtKB/TrEMBL

G4SFM6

Conserved Domains (3) summary

smart00229
Location:64 → 191

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:234 → 495

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cl00155
Location:732 → 823

UBQ; Ubiquitin-like proteins
NM_001129668.5 → NP_001123140.1 Ral guanine nucleotide dissociation stimulator-like 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123140.1

Status: REVIEWED

UniProtKB/TrEMBL

Q19852

Conserved Domains (3) summary

smart00229
Location:84 → 211

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:254 → 515

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cl00155
Location:752 → 843

UBQ; Ubiquitin-like proteins