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immt-1 MICOS complex subunit MIC60-1 [ Caenorhabditis elegans ]

Gene ID: 180566, updated on 2-Nov-2024

Summary

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Official Symbol
immt-1
Official Full Name
MICOS complex subunit MIC60-1
Primary source
WormBase:WBGene00020511
Locus tag
CELE_T14G11.3
See related
AllianceGenome:WB:WBGene00020511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cristae formation and response to reactive oxygen species. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See immt-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (2682754..2687184, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Membrane-associated protein Neighboring gene TNFR-Cys domain-containing protein Neighboring gene Ig-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans. Wu X, et al. NPJ Aging, 2023 Aug 1. PMID 37528117, Free PMC Article
  2. A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology. Zhou J, et al. Nat Cell Biol, 2022 Apr. PMID 35418624
  3. Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology. Mun JY, et al. J Cell Physiol, 2010 Sep. PMID 20578245
  4. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Head BP, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248201, Free PMC Article
  5. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the two C. elegans mitofilin isoforms, immt-1 and -2, have non-overlapping functions in controlling mitochondrial cristae formation.
    Title: Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MICOS complex subunit MIC60-1
NP_508475.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    2682754..2687184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076074.8 → NP_508475.2  MICOS complex subunit MIC60-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508475.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22505
    Conserved Domains (1) summary
    pfam09731
    Location:64 → 671
    Mitofilin; Mitochondrial inner membrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22505.2

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