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pdk-1 3-phosphoinositide-dependent protein kinase 1 [ Caenorhabditis elegans ]

Gene ID: 180475, updated on 23-Jan-2025

Summary

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Official Symbol
pdk-1
Official Full Name
3-phosphoinositide-dependent protein kinase 1
Primary source
WormBase:WBGene00003965
Locus tag
CELE_H42K12.1
See related
AllianceGenome:WB:WBGene00003965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase activity. Involved in several processes, including cellular response to reactive oxygen species; dauer larval development; and regulation of synaptic assembly at neuromuscular junction. Located in axon; neuronal cell body; and nucleus. Is expressed in several structures, including gonad; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pdk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (1321344..1327986)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Apple domain-containing protein Neighboring gene CX domain-containing protein Neighboring gene Transthyretin-like family protein Neighboring gene INSulin related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans PIAK, a phospholipid-independent kinase that activates the AKT/PKB survival kinase. Li Y, et al. J Biol Chem, 2001 Jun 8. PMID 11274160
  2. Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1). Li FC, et al. Parasit Vectors, 2016 Feb 3. PMID 26842781, Free PMC Article
  3. Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Ching TT, et al. Aging Cell, 2011 Jun. PMID 21348927, Free PMC Article
  4. Endogenous RNAi and adaptation to environment in C. elegans. Grishok A. Worm, 2012 Apr 1. PMID 24058837, Free PMC Article
  5. Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans. Wu M, et al. Toxicol Lett, 2017 May 5. PMID 28366735

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (PI3K)
    Title: Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a protein IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to metal ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-phosphoinositide-dependent protein kinase 1
NP_001024742.1
  • Confirmed by transcript evidence
NP_001024743.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1321344..1327986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029572.4 → NP_001024743.1  3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9UA36, Q9Y1J3
    Conserved Domains (3) summary
    smart00220
    Location:69 → 364
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:464 → 570
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:67 → 364
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

  2. NM_001029571.4 → NP_001024742.1  3-phosphoinositide-dependent protein kinase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y1J3
    Conserved Domains (3) summary
    smart00220
    Location:69 → 362
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:460 → 566
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:67 → 362
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y1J3.1

Gene LinkOut

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