rme-6 Receptor-mediated endocytosis protein 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rme-6
Official Full Name: Receptor-mediated endocytosis protein 6
Primary source: WormBase:WBGene00004377
Locus tag: CELE_F49E7.1
See related: AllianceGenome:WB:WBGene00004377
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables small GTPase binding activity. Involved in endocytosis; molting cycle; and regulation of clathrin-dependent endocytosis. Located in clathrin-coated endocytic vesicle; early endosome; and plasma membrane. Is expressed in several structures, including anterior gonad arm; coelomocyte; intestine; oocyte; and pharynx. Orthologous to human GAPVD1 (GTPase activating protein and VPS9 domains 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rme-6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (1097152..1103320)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RME-6 activates Rab5 in clathrin-coated pits or clathrin-coated vesicles and is essential for the delivery of endocytic cargo to early endosomes.
Title: Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F49E7.2 (e-PCR)
- UniSTS:322156

C05D9.6 (e-PCR)
- UniSTS:313473

F49E7.1 (e-PCR)
- UniSTS:311696

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activating protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, collagen and cuticulin-based cuticle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Receptor-mediated endocytosis protein 6

NP_001379623.1

Confirmed by transcript evidence

NP_508208.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1097152..1103320

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075807.6 → NP_508208.2 Receptor-mediated endocytosis protein 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508208.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4VQC9, Q8MNR6, Q9GYH7

Conserved Domains (2) summary

smart00167
Location:990 → 1093

VPS9; Domain present in VPS9

cd05129
Location:93 → 437

RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
NM_001392724.1 → NP_001379623.1 Receptor-mediated endocytosis protein 6 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl19569
Location:1 → 94

VPS9; Vacuolar sorting protein 9 (VPS9) domain