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sms-2 Phosphatidylcholine:ceramide cholinephosphotransferase 2 [ Caenorhabditis elegans ]

Gene ID: 180445, updated on 9-Dec-2024

Summary

Official Symbol
sms-2
Official Full Name
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Primary source
WormBase:WBGene00004893
Locus tag
CELE_F53H8.4
See related
AllianceGenome:WB:WBGene00004893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See sms-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (944826..948883, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Schwannomin interacting protein 1 C-terminal domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Beta-arrestin arr-1 Neighboring gene AP-3 complex subunit mu

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ceramide cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
 
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingomyelin synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables sphingomyelin synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Phosphatidylcholine:ceramide cholinephosphotransferase 2
NP_508182.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    944826..948883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075781.6NP_508182.1  Phosphatidylcholine:ceramide cholinephosphotransferase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508182.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20735
    Conserved Domains (1) summary
    pfam14360
    Location:201273
    PAP2_C; PAP2 superfamily C-terminal