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rund-1 RUN domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180416, updated on 4-Jan-2025

Summary

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Official Symbol
rund-1
Official Full Name
RUN domain-containing protein
Primary source
WormBase:WBGene00020572
Locus tag
CELE_T19D7.4
See related
AllianceGenome:WB:WBGene00020572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables small GTPase binding activity. Involved in several processes, including dense core granule maturation; positive regulation of behavior; and positive regulation of dense core granule transport. Located in several cellular components, including Golgi trans cisterna; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including gonad; intestine; nervous system; pharynx; and rectal gland cell. Orthologous to human RUNDC1 (RUN domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rund-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (658477..661777, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Galectin Neighboring gene IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LiPocalin-Related protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene LRRcap domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans. Hwang HY, et al. Sci Rep, 2021 May 26. PMID 34040027, Free PMC Article
  2. Two Rab2 interactors regulate dense-core vesicle maturation. Ailion M, et al. Neuron, 2014 Apr 2. PMID 24698274, Free PMC Article
  3. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dense core granule maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dense core granule transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of dense core granule transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RUN domain-containing protein
NP_508136.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    658477..661777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075735.8 → NP_508136.2  RUN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508136.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22585, X2C018
    Conserved Domains (2) summary
    COG1196
    Location:45 → 256
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd17683
    Location:225 → 534
    RUN_RUNDC1; RUN domain found in RUN domain-containing protein 1 (RUNDC1) and similar proteins
Nucleotide Protein
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