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dve-1 Homeobox protein dve-1 [ Caenorhabditis elegans ]

Gene ID: 180398, updated on 4-Jan-2025

Summary

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Official Symbol
dve-1
Official Full Name
Homeobox protein dve-1
Primary source
WormBase:WBGene00022861
Locus tag
CELE_ZK1193.5
See related
AllianceGenome:WB:WBGene00022861
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding activity; and protein-folding chaperone binding activity. Involved in embryo development; mitochondrial unfolded protein response; and regulation of innate immune response. Located in chromatin; cytosol; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including arcade cell; intestine; midbody; nervous system; and rectum. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB1 (SATB homeobox 1) and SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dve-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (427035..433812, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene tRNA-Gln Neighboring gene Cuticle collagen 19 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysosomal dysfunction by inactivation of V-ATPase drives innate immune response in C. elegans. Pu X, et al. Cell Rep, 2024 May 28. PMID 38678555
  2. The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling. Alexander KD, et al. Nat Commun, 2023 Nov 18. PMID 37980357, Free PMC Article
  3. The UPR(mt) Protects Caenorhabditis elegans from Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway. Oks O, et al. Genetics, 2018 Jun. PMID 29599115, Free PMC Article
  4. The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases. Zhou Z, et al. Ageing Res Rev, 2022 Nov. PMID 35908669
  5. Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans. Liu P, et al. Sci Rep, 2019 Nov 11. PMID 31712608, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Homeobox protein dve-1
NP_001024984.1
  • Confirmed by transcript evidence
NP_001338861.1
  • Confirmed by transcript evidence
NP_001370744.1
  • Confirmed by transcript evidence
NP_001380218.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    427035..433812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392715.1 → NP_001380218.1  Homeobox protein dve-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00389
    Location:176 → 241
    HOX; Homeodomain

  2. NM_001383518.2 → NP_001370744.1  Homeobox protein dve-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00389
    Location:179 → 244
    HOX; Homeodomain

  3. NM_001029813.7 → NP_001024984.1  Homeobox protein dve-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024984.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1X7RBT0, A0A1X7RBW4, Q86MH8, Q86MI0
    Conserved Domains (2) summary
    smart00389
    Location:387 → 452
    HOX; Homeodomain
    cd11585
    Location:2 → 100
    SATB1_N; N-terminal domain of SATB1 and similar proteins

  4. NM_001351875.4 → NP_001338861.1  Homeobox protein dve-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00389
    Location:384 → 449
    HOX; Homeodomain
    cd11585
    Location:2 → 100
    SATB1_N; N-terminal domain of SATB1 and similar proteins

RNA

  1. NR_147826.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86MI0.1

Gene LinkOut

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