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grd-2 Ground-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180349, updated on 4-Jan-2025

Summary

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Official Symbol
grd-2
Official Full Name
Ground-like domain-containing protein
Primary source
WormBase:WBGene00001691
Locus tag
CELE_F46B3.5
See related
AllianceGenome:WB:WBGene00001691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cholesterol binding activity; endopeptidase activity; and signaling receptor binding activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in excretory duct and excretory pore. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal (multiple); Hirschsprung's disease; bone development disease (multiple); holoprosencephaly (multiple); and polydactyly (multiple). Orthologous to human IHH (Indian hedgehog signaling molecule); DHH (desert hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See grd-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (20609794..20613929)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TransThyretin-Related family domain Neighboring gene Neuropeptide-Like Protein Neighboring gene TransThyretin-Related family domain Neighboring gene pseudo Neighboring gene DUF281 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
  2. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520
  3. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao L, et al. BMC Genomics, 2006 Oct 31. PMID 17076889, Free PMC Article
  4. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
  5. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. Bürglin TR. BMC Genomics, 2008 Mar 11. PMID 18334026, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cholesterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Ground-like domain-containing protein
NP_507977.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20609794..20613929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075576.4 → NP_507977.2  Ground-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507977.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XV14
    Conserved Domains (2) summary
    cd00081
    Location:742 → 889
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam04155
    Location:41 → 118
    Ground-like; Ground-like domain
Nucleotide Protein
Heading Accession and Version

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