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clec-49 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180298, updated on 4-Jan-2025

Summary

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Official Symbol
clec-49
Official Full Name
C-type lectin domain-containing protein
Primary source
WormBase:WBGene00012251
Locus tag
CELE_W04E12.6
See related
AllianceGenome:WB:WBGene00012251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monosaccharide binding activity and signaling receptor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See clec-49 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (19748961..19751226, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Kinesin-associated protein 3-like Neighboring gene LEM domain-containing protein;TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel C-type lectin secreted by a tissue-dwelling parasitic nematode. Loukas A, et al. Curr Biol, 1999 Jul 29-Aug 12. PMID 10469567
  2. Genome-wide evaluation of the interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during in vivo biofilm formation. Joshua GW, et al. Infect Immun, 2015 Jan. PMID 25312958, Free PMC Article
  3. The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection. Miltsch SM, et al. Dev Comp Immunol, 2014 Jul. PMID 24534554
  4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two c-type lectin-like domain proteins, Clec-39 and Clec-49, are crucial for C. elegans immunity to S. marcescens infection.
    Title: The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monosaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
C-type lectin domain-containing protein
NP_507829.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    19748961..19751226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075428.5 → NP_507829.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507829.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUL6
    Conserved Domains (1) summary
    smart00034
    Location:31 → 146
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Nucleotide Protein
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Gene LinkOut

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