Neurog1 neurogenin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neurog1provided by MGI
Official Full Name: neurogenin 1provided by MGI
Primary source: MGI:MGI:107754
See related: Ensembl:ENSMUSG00000048904 AllianceGenome:MGI:107754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AKA; ngn1; Math4C; bHLHa6; Neurod3
Summary: Enables E-box binding activity and chromatin binding activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including inner ear morphogenesis; positive regulation of exit from mitosis; and regulation of neuron differentiation. Located in perikaryon. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; neurogenic placode; and sensory organ. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (56398291..56399993, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (56250478..56252180, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identifies a requirement for Neurog1 activity in the dispersal of newborn inhibitory interneurons from the presumptive white matter tracts of the cerebellum in postnatal mice.
Title: Conditional deletion of Neurog1 in the cerebellum of postnatal mice delays inhibitory interneuron maturation.
Neurog1 thus employs different mechanisms to temper the pace of early neocortical neurogenesis.
Title: A non-canonical role for the proneural gene Neurog1 as a negative regulator of neocortical neurogenesis.
CTCF plays an essential role in otic neurogenesis by modulating histone modification in the Neurog1 locus.
Title: CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus.
NEUROG1 promotes proliferation and neuronal differentiation in otic progenitors via regulation of CDK2 expression.
Title: NEUROG1 Regulates CDK2 to Promote Proliferation in Otic Progenitors.
Ngn1 binds to the promoter of a brain-enriched microRNA, miR-9, and activates its expression during neurogenesis.
Title: Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification.
Neurog1-CreER GIFM reveals a correlation between the timing of Neurog1 expression and the spatial organization of GABAergic neurons in the cerebellar cortex.
Title: Neurog1 Genetic Inducible Fate Mapping (GIFM) Reveals the Existence of Complex Spatiotemporal Cyto-Architectures in the Developing Cerebellum.
Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development.
Title: Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development.
Neurog1 and Neurog2 have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons
Title: Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex.
ESC expressing Neurogenin1 begin to withdraw from cycle and form precursors that differentiate exclusively into neurons.
Title: Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
Netrin-1 serves as an attractive guidance cue for Neurog1-induced cells and that this effect is likely mediated by DCC receptor expressed in the growth cones of neurons.
Title: Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Neurog1 (e-PCR), detects polymorphism
- UniSTS:470669

Neurog1 (e-PCR), detects polymorphism
- UniSTS:531345

Neurog1 (e-PCR), detects polymorphism
- UniSTS:547738

Neurog1 (e-PCR), detects polymorphism
- UniSTS:502684

UniSTS:265421 (e-PCR)
- UniSTS:265421

Neurog1 (e-PCR), detects polymorphism
- UniSTS:265421

Neurog1 (e-PCR), detects polymorphism
- UniSTS:507880

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory behavior	IEA Inferred from Electronic Annotation more info
involved_in auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hard palate morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hard palate morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in learned vocalization behavior	IEA Inferred from Electronic Annotation more info
involved_in learned vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in mastication	IEA Inferred from Electronic Annotation more info
involved_in mastication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of relaxation of muscle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of saliva secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peristalsis	IEA Inferred from Electronic Annotation more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in thorax and anterior abdomen determination	IEA Inferred from Electronic Annotation more info
involved_in thorax and anterior abdomen determination	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	IEA Inferred from Electronic Annotation more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve formation	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurogenin-1

Names: NGN-1; helix-loop-helix protein mATH-4C; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010896.3 → NP_035026.1 neurogenin-1

See identical proteins and their annotated locations for NP_035026.1

Status: VALIDATED

Source sequence(s)

AC124395

Consensus CDS

CCDS26559.1

UniProtKB/Swiss-Prot

P70660

Related

ENSMUSP00000050484.5, ENSMUST00000058475.6

Conserved Domains (1) summary

cd00083
Location:91 → 150

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...