U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nhr-112 Nuclear receptor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180115, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
nhr-112
Official Full Name
Nuclear receptor domain-containing protein
Primary source
WormBase:WBGene00003702
Locus tag
CELE_Y70C5C.6
See related
AllianceGenome:WB:WBGene00003702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in nucleus. Is expressed in several structures, including head; hypodermis; pharynx; reproductive system; and tail. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nhr-112 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (16722061..16723844, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene Peptidase_M75 domain-containing protein Neighboring gene ncRNA Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Arda HE, et al. Mol Syst Biol, 2010 May 11. PMID 20461074, Free PMC Article
  2. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article
  3. Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions. Zárate-Potes A, et al. Front Microbiol, 2022. PMID 35620104, Free PMC Article
  4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Nuclear receptor domain-containing protein
NP_001024286.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16722061..16723844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029115.6 → NP_001024286.1  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62496
    Conserved Domains (2) summary
    smart00399
    Location:2 → 67
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    smart00430
    Location:138 → 310
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools