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cpl-1 Cathepsin L-like [ Caenorhabditis elegans ]

Gene ID: 180111, updated on 14-Nov-2024

Summary

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Official Symbol
cpl-1
Official Full Name
Cathepsin L-like
Primary source
WormBase:WBGene00000776
Locus tag
CELE_T03E6.7
See related
AllianceGenome:WB:WBGene00000776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Is expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cpl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (16592572..16595346, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans. Murray L, et al. Int J Parasitol, 2007 Aug. PMID 17451718
  2. A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1. Ultaigh SN, et al. Exp Parasitol, 2009 Apr. PMID 19059238
  3. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. Hashmi S, et al. J Biol Chem, 2002 Feb 1. PMID 11707440
  4. A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes. Britton C, et al. Mol Biochem Parasitol, 2002 Jun. PMID 12076767
  5. The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Xu M, et al. Mol Biol Cell, 2014 Jul 1. PMID 24829385, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reveals a previously undescribed molecular mechanism by which peripheral CPL-1/cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin signaling.
    Title: Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.
  2. cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos
    Title: Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
  3. CPL-1 is the leading lysosomal protease required for elimination of apoptotic cells in C. elegans.
    Title: The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.
  4. pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
    Title: A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
  5. Cathepsin L protease (CPL-1) has a critical role in yolk processing during embryogenesis in Caenorhabditis elegans
    Title: Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid droplet disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vitellogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptosis involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endolysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in phagolysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in yolk granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Cathepsin L-like
NP_001256718.1
  • Confirmed by transcript evidence
NP_001256719.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16592572..16595346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269789.4 → NP_001256718.1  Cathepsin L-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G333, O45734
    Conserved Domains (2) summary
    pfam00112
    Location:120 → 335
    Peptidase_C1; Papain family cysteine protease
    pfam08246
    Location:32 → 91
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

  2. NM_001269790.3 → NP_001256719.1  Cathepsin L-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G333
    Conserved Domains (1) summary
    pfam00112
    Location:1 → 196
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45734.1

Gene LinkOut

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