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his-3 Histone H2A [ Caenorhabditis elegans ]

Gene ID: 180073, updated on 4-Jan-2025

Summary

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Official Symbol
his-3
Official Full Name
Histone H2A
Primary source
WormBase:WBGene00001877
Locus tag
CELE_T10C6.12
See related
AllianceGenome:WB:WBGene00001877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See his-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_003283.11 (16040808..16041191)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Histone H2B 2 Neighboring gene ncRNA Neighboring gene Histone H3 Neighboring gene Histone H4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis. Zedek F, et al. PLoS One, 2012. PMID 22291967, Free PMC Article
  2. The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity. Takahashi Y, et al. J Recept Signal Transduct Res, 2011 Apr. PMID 21385054
  3. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. Bessler JB, et al. PLoS Genet, 2010 Jan 22. PMID 20107519, Free PMC Article
  4. Differential chromatin marking of introns and expressed exons by H3K36me3. Kolasinska-Zwierz P, et al. Nat Genet, 2009 Mar. PMID 19182803, Free PMC Article
  5. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, et al. Nature, 2007 Oct 11. PMID 17713478

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular characterization of NAP1 chaperoning activity toward histones H2A/H2B has been reported.
    Title: Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B.
  2. Although CENP-C did not show any signs of positive selection, positive selection has been detected in the case of CENH3.
    Title: Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis.
  3. H3K9me2 and H3K9me3 are highly autonomous chromatin modifications, functioning independently in the germ line.
    Title: Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
  4. H3K36me3 exon marking in chromatin provides a dynamic link between transcription and splicing.
    Title: Differential chromatin marking of introns and expressed exons by H3K36me3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone H2A
NP_507032.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16040808..16041191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074631.5 → NP_507032.1  Histone H2A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09588, Q7JKF5
    Conserved Domains (1) summary
    PTZ00017
    Location:18 → 127
    PTZ00017; histone H2A; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09588.2

Gene LinkOut

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